InterTAK Diagnostic Score Calculator

About the InterTAK Score

The InterTAK Diagnostic Score was developed by the International Takotsubo Registry, led by Dr. Jelena R. Ghadri and colleagues at the University Hospital Zurich, Switzerland.

Original Publication: Ghadri JR, Cammann VL, Jurisic S, et al. A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry. European Journal of Heart Failure 2017;19(8):1036-1042. doi:10.1002/ejhf.683

Middle Eastern Validation: This calculator incorporates findings from the validation study by Jamil G, Al Shamisi A, AlShamsi F, Agha A at Tawam Hospital, UAE, which identified an optimal cutoff of ≥36 for Middle Eastern populations (90.9% sensitivity, 100% specificity). J Clin Med 2025 (In Press).

Calculate InterTAK Score

Female sex 25 pts

Emotional trigger 24 pts

Physical trigger 13 pts

Absence of ST-segment depression 12 pts

Psychiatric disorders 11 pts

Neurologic disorders 9 pts

QTc prolongation 6 pts

Total Score

out of 100 possible points

Clinical Interpretation

Score < 31: High probability of ACS

Sensitivity

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Specificity

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PPV

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NPV

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Clinical Recommendation:

Calculate the InterTAK score at initial presentation for patients with suspected ACS.

Key References

Ghadri JR, Cammann VL, Jurisic S, et al. A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry. Eur J Heart Fail. 2017;19(8):1036-1042.
Jamil G, Al Shamisi A, AlShamsi F, Agha A. Validation of the InterTAK Diagnostic Score for Differentiating Takotsubo Syndrome from Acute Coronary Syndrome in a Middle Eastern Population. J Clin Med. 2025;14:xxx. [In Press]
Ghadri JR, Wittstein IS, Prasad A, et al. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. Eur Heart J. 2018;39(22):2032-2046.